Tetanus toxoid adsorbed vaccine


Thông tin thuốc gốc
Chỉ định và Liều dùng
Intramuscular
Prophylaxis of tetanus in wound management
Adult: Consider the immunisation status of the patient and the type and condition of the wound. Non-immunised or partially immunised patients, uncertain vaccination history; completely immunised and >10 years since last booster dose: 0.5 mL (≥40 IU) to be given immediately. Completely immunised patients with minor, clean wounds who have been vaccinated within the last 5-10 years may not need a prophylaxis dose. Non-immunised or partially immunised patients or those with uncertain vaccination history are recommended to start and complete a primary series. Refer to detailed product or local treatment guidelines for specific dosing recommendations.

Intramuscular
Active immunisation against tetanus
Adult: As ≥40 IU/0.5 mL preparation: Primary immunisation: 0.5 mL for 2 doses, given 4-8 weeks apart, followed by a 3rd dose of 0.5 mL 6-12 months after the 2nd dose. Booster dose: 0.5 mL every 10 years. For neonatal tetanus prophylaxis in pregnant women, the 1st dose is preferably administered ≥90 days prior to birth.
Child: Neonates, infants, children, and adolescents Primary immunisation: Same as adult dose. Treatment recommendations may vary per country; refer to local product guidelines and paediatric vaccine schedules for specific recommendations.
Chống chỉ định
Hypersensitivity. Neurological disorder following a previous dose of vaccine.
Thận trọng
Patient with bleeding disorders (including thrombocytopenia) or vitamin K deficiency, history of respiratory immaturity. Patient who developed Guillain-Barre syndrome within 6 weeks of receiving tetanus toxoid-containing vaccine. Defer immunisation in patients with acute infection or febrile illness; vaccination may be given in patients with mild acute illness (with or without fever). Consider delaying vaccination in patients with severe immunosuppression (e.g. receiving chemotherapy/radiation therapy or high-dose corticosteroids) until the end of the treatment; vaccination in patients with chronic immunosuppression (e.g. HIV infection) is recommended. Avoid vaccination more frequently than every 10 years in patients who have experienced Arthus-type hypersensitivity reaction following vaccination of tetanus toxoid. Patient receiving anticoagulant therapy. Very premature infants (born ≤28 weeks of gestation); infants and children (particularly if with neurological disease, history of febrile seizure, or cerebral damage). Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Anaphylactoid or hypersensitivity reactions (including Arthus-type hypersensitivity), syncope, Guillain-Barre syndrome, brachial neuritis.
Blood and lymphatic system disorders: Lymphadenopathy, thrombocytopenia.
Gastrointestinal disorders: Nausea.
General disorders and administration site conditions: Inj site reactions (e.g. inflammation, warm sensation, pain, rash, induration, oedema; nodules which may develop into aseptic abscess), transient fever, malaise, irritability.
Musculoskeletal and connective tissue disorders: Myalgia, arthralgia.
Nervous system disorders: Dizziness, headache.
Respiratory, thoracic and mediastinal disorders: Apnoea (particularly in very premature infants).
Skin and subcutaneous tissue disorders: Urticaria, erythema nodosum, generalised pruritus, rash.
Vascular disorders: Hypotension.
IM/Parenteral/SC: C
Chỉ số theo dõi
Monitor for hypersensitivity reaction and syncope for at least 15 minutes post-vaccination.
Tương tác
May decrease therapeutic effect with immunosuppressants. Risk of haematoma or bleeding following IM inj in patients receiving anticoagulant therapy.
Tác dụng
Description:
Mechanism of Action: Tetanus toxoid adsorbed vaccine is a preparation of inactivated toxin produced by virulent tetanus bacilli (detoxified growth product of Clostridium tetani). It acts as an antigen and produces active immunity against tetanus.
Duration: Immunity: Approx 10 years.
Bảo quản
Store between 2-8°C. Protect from light. Do not freeze. Opened multidose vials may be stored for up to 4 weeks under appropriate cold chain conditions.
Phân loại MIMS
Vaccin, kháng huyết thanh & thuốc miễn dịch
Phân loại ATC
J07AM01 - tetanus toxoid ; Belongs to the class of tetanus bacterial vaccines.
Tài liệu tham khảo
Anon. Tetanus Toxoid (Adsorbed). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/08/2022.

Buckingham R (ed). Tetanus Vaccines. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/08/2022.

Tetana, Suspension for Injection (Bionovel Co., Ltd). MIMS Thailand. http://www.mims.com/thailand. Accessed 10/08/2022.

Tetanus Toxoid Vaccine Adsorbed (SM Pharmaceuticals Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 10/08/2022.

Tetanus Toxoid. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 16/08/2022.

Tetanus: For Clinicians. Centers for Disease Control and Prevention. https://www.cdc.gov. Accessed 16/08/2022.

Tetavax Single Dose, Suspension for Injection in a Prefilled Syringe (Sanofi-Aventis Singapore Pte Ltd). MIMS Singapore. http://www.mims.com/singapore. Accessed 10/08/2022.

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